Cardio-oncology & otherCohort study
Clinical and Echocardiographic Phenotype of Cardiac Wasting in Patients with Advanced Cancer
- Prospective cohort study
Authors' conclusion
Patients with advanced cancer with low LV mass have a distinct phenotype characterized by lower cardiac chamber volumes, stroke volume, and cardiac output, but normal LVEF and GLS that may be the distinct feature of cardiac wasting-associated cardiomyopathy.
Study context
- Population
- Patients with active, mostly advanced cancer without significant CVD or active infection143 with follow-up
- Participants
- 398 patients
- Exposure
- Quartiles of LV mass/height2
Main finding
As reported in the abstract
Phenotype by LV mass/height2 quartile
- LVEF, global longitudinal strain (GLS) and anticancer therapy naive status similar across quartiles
- Q1 younger, more likely cachectic, lower BMI, 10-step stair-climbing power, tricuspid annular plane systolic excursion (TAPSE), stroke volume, cardiac output, and higher heart rate
Observational data: associations, not effects.
Further findings
Change at repeat follow-up · 140 ± 8 days
- LVEF, TAPSE, LV mass, left atrial volume and GLS reduced
- all p ≤ 0.002
- Above-median baseline LV mass: cardiac output and heart rate increased; below-median: mitral E/A decreased
- n = 143
Original publication
Clinical and Echocardiographic Phenotype of Cardiac Wasting in Patients with Advanced Cancer. Eur J Heart Fail. Published 6 August 2025. doi:10.1002/ejhf.3744
Summarised from the published abstract; every number is checked against it