Coronary disease & ACSCohort study
Clinical and economic outcomes following first-time myocardial infarction: a nationwide cohort study from the SWEDEHEART registry
- nationwide cohort study
- matched controls (matched by sex, age, and region)
Authors' conclusion
First-time MI patients have persistently higher risks of cardiovascular death, MI, and ischaemic stroke, along with greater healthcare use and costs, underscoring the need for effective prevention.
Study context
- Population
- First-time myocardial infarction (MI) patients from the nationwide SWEDEHEART registry and matched controls without prior MI, 2012–2022first-time MI patients 118,810 · matched controls 588,687
- Participants
- 118,810 vs 588,687
- Exposure
- comparing outcomes, healthcare resource use, and associated costs between first-time MI patients and matched controls
- first-time MI patientsn = 118,810
- matched controlsn = 588,687reference
Main finding
As reported in the abstract
Major adverse cardiovascular events (MACE):
- Cardiovascular death
- MI
- Ischaemic stroke
- Acute limb ischaemia
- Urgent arterial revascularization
first-time MI patients vs matched controlsEstimate (95% CI)
MACE (cardiovascular death, MI, ischaemic stroke, acute limb ischaemia, or urgent arterial revascularization)
HR 3.65(3.61–3.69)
after adjustment for baseline characteristics
adjHR 3.18(3.15–3.22)
Observational data: associations, not effects.
Further findings
Cardiovascular death, MI, arterial revascularization · 10-year
cardiovascular death
MI
arterial revascularization
| Outcome | first-time MI patients | matched controls |
|---|---|---|
| Healthcare resource use and costs | ||
| inpatient visits | 0.65/patient year | 0.32/patient year |
| inpatient days | 3.05/patient year | 1.67/patient year |
| mean annual total costs | €7266 | €3934 |
Healthcare resource use and costs
- Differences were greatest in the first year but persisted, especially among females and those with risk factors such as hypertension or diabetes
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Clinical and economic outcomes following first-time myocardial infarction: a nationwide cohort study from the SWEDEHEART registry. Eur Heart J Qual Care Clin Outcomes. Published 25 April 2026. doi:10.1093/ehjqcco/qcag071
Summarised from the published abstract; every number is checked against it