Heart failure & cardiomyopathiesCohort study
Clinical and prognostic significance of central and obstructive apnoeas in patients with transthyretin cardiac amyloidosis
- Prospective cohort study
- consecutive patients
Authors' conclusion
Both CA and OA are highly prevalent, both at daytime and nighttime, in patients with ATTR-CA and are associated with higher mortality.
Study context
- Population
- Patients with ATTR-CA undergoing 24 h ambulatory cardiorespiratory monitoring (aged 77 ± 7 years, 91% males, 96% wild-type)
- Participants
- 142 patients
- Exposure
- Central apnoea (CA) vs obstructive apnoea (OA) vs normal breathing (NB)
- Outcome
- All-cause mortality
- Follow-up
- Median 2.3-year (1.4-3.3 years)
Main finding
As reported in the abstract
median 2.3 years
Each group vs NBHazard ratio (95% CI)P value
Nighttime AHI ≥30 events/h
2.37(1.07–5.23)
P = 0.033High-sensitivity troponin T
2.43(1.42–4.17)
P = 0.001- 24 h, daytime and nighttime apnoea-hypopnoea index (AHIs) higher in non-survivors vs survivors
- all P < 0.05
- Independent of prevalent apnoea type
- P = 0.64
Observational data: associations, not effects.
Further findings
Prevalence of breathing disorders (24 h; daytime; nighttime)
Daytime
Nighttime
Original publication
Clinical and prognostic significance of central and obstructive apnoeas in patients with transthyretin cardiac amyloidosis. Eur J Prev Cardiol. Published 23 September 2024. doi:10.1093/eurjpc/zwae297
Summarised from the published abstract; every number is checked against it