Heart failure & cardiomyopathiesMeta-analysis
Clinical Characteristics and Outcomes of Patients Aged 80 Years and Over with Heart Failure: Need for Better Treatment
- Individual participant meta-analysis of randomised trials
Authors' conclusion
Despite worse health status and higher hospitalization and mortality rates, octogenarians were undertreated compared to younger patients.
Study context
- Population
- Patients with HFrEF, HFmrEF or HFpEF enrolled in 8 large randomised trials8 RCTs
- Comparison
- Octogenarians vs patients aged <80 years
- Outcome
- Composite of:
- CV death
- HF hospitalisation
Pooled result
As reported in the abstract
CV death or HF hospitalisation (per 100 person-years)
Adjusted hazard ratio
1.40
95% CI 1.32–1.48
By group
Octogenarians vs Non-octogenarians
adjusted HR 1.40 (95% CI 1.32–1.48)
Further pooled results
per 100 person-years
| Outcome | Octogenarians | Non-octogenarians | adjusted HR (95% CI) | P value | |
|---|---|---|---|---|---|
| CV mortality (per 100 person-years) | 7.0 (95% CI 6.5–7.4) | 4.9 (95% CI 4.8–5.1) | 1.60 (1.48–1.72) | P < 0.001 | |
| 0.512Adjusted hazard ratio (log scale) |
Proportion of octogenarians by heart failure (HF) phenotype
- HFrEF
- 1518 of 20 168 (7.5%)
- HFmrEF
- 610 of 4609 (13.2%)
- HFpEF
- 3130 of 15 354 (20.4%)
Evidence-based therapy
- Octogenarians received less evidence-based therapy, especially MRAs, than younger patients
Original publication
Clinical Characteristics and Outcomes of Patients Aged 80 Years and Over with Heart Failure: Need for Better Treatment. Eur J Heart Fail. Published 21 August 2024. doi:10.1002/ejhf.3417
Summarised from the published abstract; every number is checked against it