Valvular & structural heart diseaseCohort study
Clinical Characteristics and Outcomes of Patients Screened for Transcatheter Tricuspid Valve Replacement
- Multicentre observational study
- 7 centres
- compassionate use
Authors' conclusion
This first real-world report of TTVR screening demonstrated a high screening failure rate, mainly related to large tricuspid annular diameter. Patients undergoing TTVR had superior TR reduction and symptom alleviation compared with bailout tricuspid transcatheter edge-to-edge repair, at the cost of greater procedural complications.
Study context
- Population
- Patients with tricuspid regurgitation (TR) screened for transcatheter tricuspid valve replacement (TTVR) at 7 centres on a compassionate-use basisscreened
- Participants
- 149 patients
- Exposure
- TTVR vs bailout tricuspid TEER after failed TTVR screening
- Outcome
- NYHA functional class and TR grade
- Follow-up
- 30-day follow-up
Main finding
As reported in the abstract
NYHA class I or II (baseline to 30 days) and TR ≤1+ at 30 days
| Group | NYHA I or II | TR ≤1+ |
|---|---|---|
| TTVR | from 21% to 68%; P < 0.001 | 97% (P < 0.001 from baseline) |
| Bailout TEER | from 27% to 58%; P < 0.001 | 43% (P < 0.001 from baseline) |
Observational data: associations, not effects.
Secondary outcomes
TTVR screening failure rate
- Screening failure rate, mainly large tricuspid annular diameter
- 74%
Technical success
- Technical success
- 91%
All-cause mortality · 30 days
- Mortality
- 8%
HF hospitalization · 30 days
- HF hospitalization
- 5%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Clinical Characteristics and Outcomes of Patients Screened for Transcatheter Tricuspid Valve Replacement. JACC Cardiovasc Interv. Published 26 February 2024. doi:10.1016/j.jcin.2023.12.016
Summarised from the published abstract; every number is checked against it