Valvular & structural heart diseaseCohort study
Clinical Characteristics and Outcomes of Patients Undergoing 3 Aortic Valve Interventions
- Retrospective cohort study
- multicentre
- international
- registry
Authors' conclusion
In the THIRD registry, SVD emerged as the predominant indication for a third aortic valve procedure. The most frequent procedure sequence was SAVR-SAVR-TAVR, whereas TAVR-TAVR-TAVR was less common.
Study context
- Population
- Patients undergoing a third aortic valve procedure (surgical or transcatheter), THIRD registry, 11 centres
- Participants
- 51 patients · 11 centres
- Exposure
- Surgical aortic valve replacement (SAVR) vs transcatheter aortic valve replacement (TAVR) as third aortic valve intervention
- SAVRn = 18
- TAVRn = 33
Main finding
As reported in the abstract
Indications and procedure sequences for a third aortic valve intervention
- Indication: Structural valve deterioration (SVD)
- 39/51, 76%
- Indication: non-SVD
- 8/51, 16%
- Indication: endocarditis
- 2/51, 4%
- Sequence SAVR-SAVR-TAVR
- 19/51, 37%
- Sequence SAVR-SAVR-SAVR
- 10/51, 20%
- Sequence SAVR-TAVR-TAVR
- 10/51, 20%
- Sequence TAVR-TAVR-TAVR
- 4 of 51 cases (8%)
Observational data: associations, not effects.
Further findings
Predictors of SAVR as third intervention (excluding mechanical prostheses)
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| Lower STS score | 0.58 (0.34–0.98) | P = 0.04 | |
| Moderate or severe prosthesis-patient mismatch | 44.8 (2.41–122.00) | P = 0.01 | |
| 0.050.21520Odds ratio (log scale) |
Device success · 30 days
Original publication
Clinical Characteristics and Outcomes of Patients Undergoing 3 Aortic Valve Interventions. JACC Cardiovasc Interv. Published 13 January 2025. doi:10.1016/j.jcin.2024.10.037
Summarised from the published abstract; every number is checked against it