Heart failure & cardiomyopathies
Clinical characteristics, echocardiographic findings, and 6-month outcomes in Ugandan women with peripartum cardiomyopathy
Authors' conclusion
This study shows a high mortality rate of 7.5% aligning with global studies, the observed high thrombus burden and stroke occurred in 10% and 2.5%, respectively which may indicate severity of LV systolic dysfunction at presentation. Two-thirds of patients received Bromocriptine in addition to GDMT which may explain the high rate of LV recovery in this cohort.
Study context
- Population
- Women with peripartum cardiomyopathy (PPCM) in Uganda on goal-directed medical therapy (GDMT)PPCM women, 80 matched controls recruited at baseline as comparison for the biomarkers
- Participants
- 80 women
- Exposure
- PPCM cases vs matched controls
- Casesn = 80
- Controlsn = 80
- Outcome
- Age
- Follow-up
- Baseline
Methodological detailsmatched for age, matched controls
- Matched for age
- Matched controls
Main finding
As reported in the abstract
Cases
33.6 ± 6.6
mean · years
Controls
30.2 ± 5.9
mean · years
Observational data: associations, not effects.
Further findings
| Outcome | Cases | Controls |
|---|---|---|
| LVEF, LV GLS, RV GLS · baseline | ||
| Mean LVEF | 35.7 ± 11.0% | 67.2 ± 4.5% |
| Mean LV GLS | −11.9 ± 4.7% | −17.1 ± 4.9% |
| Mean RV GLS | −14.7 ± 10.9% | — not stated in the abstract |
| Death · 6 months | 7.5% | — not stated in the abstract |
| NYHA I · 6 months | 65% | — not stated in the abstract |
| LV recovery (LVEF ≥ 50%) · 6 months | 46.3% | — not stated in the abstract |
— not stated in the abstract
Left ventricular ejection fraction (LVEF), LV global longitudinal strain (GLS), RV GLS · baseline
- All controls had normal RV systolic function parameters
Baseline severity in cases
- LVEF <35%
- 22 (27.5%)
- Severe RV systolic dysfunction
- 6 (7.5%)
- NYHA IV
- 20 (25%)
- Received bromocriptine therapy in addition to other GDMT
- 54 (68%)
Safety
Atrial fibrillation and intracardiac thrombus · 6 months
- Atrial fibrillation
- 2 (2.5%)
- Intracardiac thrombus
- 8 (10%)
Original publication
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