Cardio-oncology & otherCohort study
Clinical characteristics, treatment, and outcomes in cardiac implantable electronic device (CIED)-related vs. left-sided infective endocarditis: a nationwide study from the NIDUS registry
- Nationwide registry-based cohort study
Authors' conclusion
In this nationwide study, patients with CIED-related IE were distinctly different from those with left-sided IE. Staphylococci were more prevalent, and despite higher age and differences in comorbidities, mortality was lower.
Study context
- Population
- Patients with first-time infective endocarditis, Danish NIDUS registry, 2016–2021
- Participants
- 340 vs 2,510
- Exposure
- CIED-related infective endocarditis (IE) vs left-sided valvular IE
- CIED-related IEn = 340
- Left-sided IEn = 2,510reference
- Outcome
- Mortality
- Follow-up
- 6 months
Main finding
6-month mortality
Adjusted hazard ratio
0.52
95% CI 0.40–0.68
P < 0.001
By group
CIED-related IE vs Left-sided IE
adjusted HR 0.52 (95% CI 0.40–0.68); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Baseline characteristics
Age CIED-related IE 76.1 years · Left-sided IE 73.2 years
Male
DM
HF
Staphylococcus aureus
Coagulase-negative staphylococci
Culture-negative IE
Fever at admission
- CIED removal (CIED-related IE)
- 78.2%
Original publication
Clinical characteristics, treatment, and outcomes in CIED-related vs. left-sided infective endocarditis: a nationwide study from the NIDUS registry. Europace. Published 9 April 2026. doi:10.1093/europace/euag075
Summarised from the published abstract; every number is checked against it