Congenital heart diseaseCohort study
Clinical features, haemodynamics, and outcomes of heart failure with preserved ejection fraction in coarctation of aorta
- Retrospective cohort study
- consecutive patients
Authors' conclusion
Heart failure with preserved ejection fraction is common in adults with COA and is associated with greater risk of death/transplant
Study context
- Population
- Adults with repaired coarctation of aorta (COA) who underwent right heart catheterization
- Participants
- 99 adults
- Exposure
- Heart failure with preserved ejection fraction (HFpEF) vs no HFpEF in repaired COA
- HFpEFn = 32
- Outcome
- Prevalence of HFpEF and death/transplant
Main finding
As reported in the abstract
Hazard ratio
1.68
95% CI 1.16–3.11
Events by group
HFpEF
32%
32 of 32
Without HFpEF
12%
10-year cumulative incidence of death/transplant
HFpEF vs Without HFpEF
HR 1.68 (95% CI 1.16–3.11)
- 10-year death/transplant 39% vs 12%
- P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | adjusted OR (95% CI) | |
|---|---|---|
| Correlates of HFpEF (multivariable) — Obesity vs Without HFpEF | 4.15 (1.31–13.2) | |
| Correlates of HFpEF (multivariable) — Atrial fibrillation vs Without HFpEF | 3.13 (1.00–10.7) | |
| Correlates of HFpEF (multivariable) — Total arterial compliance index · per 1 ml/mmHg*m² | 0.12 (0.06–0.41) | |
| Correlates of HFpEF (multivariable) — Pulmonary artery compliance index · per 1 ml/mmHg*m² | 0.36 (0.15–0.56) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Original publication
Clinical features, haemodynamics, and outcomes of heart failure with preserved ejection fraction in coarctation of aorta. Eur J Heart Fail. Published 16 July 2024. doi:10.1002/ejhf.3379
Summarised from the published abstract; every number is checked against it