Valvular & structural heart disease
Clinical impact of early changes in guideline-directed medical therapy after mitral valve transcatheter edge-to-edge repair
Main finding · All-cause mortality and HF rehospitalizationResult — go to the resultHazard ratio 0.62 95% CI 0.39–0.99Authors' conclusion
In patients with FMR and LVEF <50%, a higher number of GDMT classes at discharge and in-hospital uptitration of the GDMT class were associated with better outcomes
Study context
- Population
- Patients with functional mitral regurgitation and left ventricular ejection fraction (LVEF) <50% undergoing mitral transcatheter edge-to-edge repair (M-TEER), multicentre Japanese registry
- Participants
- 1,638 patients
- Exposure
- Number of guideline-directed medical therapy (GDMT) classes at discharge; GDMT change from before M-TEER to discharge
- Singlen = 183
- Doublen = 505
- Triplen = 630
- Quadruplen = 320
- Increasedn = 271
- Unchangedn = 1,219
- Decreasedn = 148reference
- Outcome
- All-cause mortality and HF rehospitalization
- Follow-up
- 1 year
Methodological detailsmulticentre
- Multicentre
Main finding
All-cause mortality and HF rehospitalization
Hazard ratio
0.62
95% CI 0.39–0.99
By group
Increased vs Decreased
HR 0.62 (95% CI 0.39–0.99)
As reported in the abstract
- Primary endpoint overall
- 357 patients (22%)
- Trend across discharge GDMT class groups
- P < 0.001
- Greater number of GDMT classes at discharge, adjusted HR
- 0.83 (95% CI 0.73-0.95)
Observational data: associations, not effects.
Original publication
Clinical impact of early changes in guideline-directed medical therapy after mitral valve transcatheter edge-to-edge repair. Eur J Heart Fail. Published 30 January 2026. doi:10.
Summarised from the published abstract; every number is checked against it