Clinical Impact of Physiology-Guided Percutaneous Coronary Intervention (PCI): 1-year Results of the Post-Revascularization Optimization and Physiological Evaluation of Intermediate Lesions using Fractional Flow Reserve (PROPHET-FFR) Study
- ambispective observational study
- propensity score matching
+1 more
- propensity score matching
Authors' conclusion
In this observational study, post-PCI physiology appears to be associated with lower 12-month MACE compared with conventional PCI, with consistent findings after propensity score matching.
Study context
- Population
- Patients undergoing invasive physiological assessment of intermediate coronary stenosesdeferred PCI 1,307 · conventional PCI 331 · post-PCI physiology 348
- Participants
- 1,986 patients
- Exposure
- post-PCI physiology vs conventional PCI
- deferred PCIn = 1,307
- conventional PCIn = 331
- post-PCI physiologyn = 348
Main finding
As reported in the abstract
MACE:
- Cardiovascular death
- Spontaneous myocardial infarction
- Target-vessel revascularization (TVR)
P = 0.019
Observational data: associations, not effects.
Further findings
| Outcome | Deferred PCI | Conventional PCI | post-PCI physiology | P value | |
|---|---|---|---|---|---|
| TVR · 12 months · reduced TVR | Not reported in the abstract | 5.4% | 2.6% | P = 0.057 | deferred PCI: not reported in the abstract |
| MACE after propensity score matching · 12 months | Not reported in the abstract | 8.0% | 2.7% | P = 0.0114 | deferred PCI: not reported in the abstract |
- Major adverse cardiovascular events (MACE) after propensity score matching: 226 patients/group
Use of post-PCI physiology across registry phases
- Post-PCI physiology increased
- from 11.8% to 22.8%
- p<0.001
Physiology-guided optimization across registry phases
- Numerical increase in physiology-guided optimization
- 11.6% vs 18.1%
- p=0.08
Original publication
Clinical Impact of Physiology-Guided PCI: 1-year Results of the Post-Revascularization Optimization and Physiological Evaluation of Intermediate Lesions using Fractional Flow Reserve (PROPHET-FFR) Study. Circ Cardiovasc Interv. Published 15 October 2026. doi:10.
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Summarised from the published abstract; every number is checked against it