Clinical implementation of partial oral treatment in infective endocarditis: the Danish POETry study
Authors' conclusion
At 6-month follow-up, there was a numerically but not statistically significant difference towards a lower incidence of the primary outcome, a lower incidence of all-cause mortality and a reduced length of stay in the PO group.
Study context
- Population
- Patients with infective endocarditis (IE) caused by S. aureus, E. faecalis, Streptococcus spp. or coagulase-negative staphylococci, diagnosed May 2019–December 2020median age 74 years, 70% males
- Participants
- 562 patients
- Exposure
- Oral step-down antibiotic therapy vs continued IV antibiotic therapy
- POn = 240
- IVn = 322reference
- Outcome
- Composite of:
- Embolic events
- Unplanned cardiac surgery
- Relapse of bacteraemia and all-cause mortality
- In patients finalizing antibiotic treatment
- Follow-up
- 6 months
Methodological detailsobservational, guideline-driven clinical implementation
- Observational
- Guideline-driven clinical implementation
Main finding
As reported in the abstract
P = 0.051
Observational data: associations, not effects.
Further findings
All-cause mortality
P = 0.024
Length of stay
P < 0.001
Original publication
Clinical implementation of partial oral treatment in infective endocarditis: the Danish POETry study. Eur Heart J. Published 25 October 2023. doi:10.
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