Coronary disease & ACSCohort study
Clinical outcomes associated with recurrent compared to first-time myocardial infarction
- nationwide registries
- matched 1:1 on age and sex
- consecutive patients
- Denmark between 2015 and 2022
Authors' conclusion
Recurrent MI is associated with a higher risk of all-cause mortality, HHF, and further recurrent MI compared with first-time MI.
Study context
- Population
- Patients with recurrent myocardial infarction (MI) and age- and sex-matched patients with first-time MI in Denmark between 2015 and 20228,397 patients with recurrent MI and 8,397 with first-time MI (median age 73, 70.7% male) · recurrent MI 8,397 · first-time MI 8,397
- Participants
- 8,397 vs 8,397
- Exposure
- Recurrent MI vs first-time MI
- recurrent MIn = 8,397
- first-time MIn = 8,397
- Outcome
- Composite of:
- All-cause mortality
- Hospitalization for heart failure (HHF)
- Further recurrent MI
- Follow-up
- 1-year
Main finding
As reported in the abstract
sRR
1.39
95% CI 1.34–1.44
By group
Observational data: associations, not effects.
Further findings
All-cause mortality
sRR 1.29 (1.24–1.35)
HHF
sRR 1.11 (1.00–1.21)
Recurrent MI
sRR 3.01 (2.71–3.45)
Use of guideline-recommended treatments postdicharge
percutaneous coronary intervention
lipid-lowering treatment
P2Y12 inhibitor
- Use of guideline-recommended treatments postdicharge: percutaneous coronary intervention P < .001
- Use of guideline-recommended treatments postdicharge: lipid-lowering treatment P < .001
- Use of guideline-recommended treatments postdicharge: P2Y12 inhibitor P < .001
Comorbidities
- Patients with recurrent MI had more comorbidities
Original publication
Clinical outcomes associated with recurrent compared to first-time myocardial infarction. Am Heart J. Published 30 August 2026. doi:10.1016/j.ahj.2026.107592
Summarised from the published abstract; every number is checked against it