Clinical outcomes in blood culture-negative versus blood culture-positive infective endocarditis: a systematic review and meta-analysis
Pooled result · Short-term mortalityResult — go to the resultRelative risk 0.95 95% CI 0.77–1.19Authors' conclusion
In this study-level meta-analysis, short-term mortality did not differ between BCNIE and BCPIE. However, complication rates varied: heart failure was more common in BCNIE, whereas embolic events were less frequent.
Study context
- Population
- Patients with infective endocarditis
- Participants
- 17,661 patients35 studies
- Comparison
- Blood culture-negative infective endocarditis (BCNIE) vs BCPIE
- Outcome
- Short-term mortality
Methodological detailsrandom-effects model, study-level
- Random-effects model
- Study-level
Pooled result
As reported in the abstract
Relative risk
0.95
95% CI 0.77–1.19
BCNIEvs BCPIE
RR 0.95 (95% CI 0.77–1.19)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| HF | 1.33 (1.16–1.51) | |
| Embolic events | 0.81 (0.69–0.95) | |
| 0.512Relative risk (log scale) |
Mortality by study design, region, sample size, publication year (subgroups)
- Mortality outcomes consistent across subgroups
Original publication
Clinical outcomes in blood culture-negative versus blood culture-positive infective endocarditis: a systematic review and meta-analysis. Heart. Published 17 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →