Cohort study
Clinical Outcomes of Adult Fontan-Associated Liver Disease and Combined Heart-Liver Transplantation
- Retrospective cohort study
- multicentre (15 centers)
- matched
Authors' conclusion
Higher FALD scores were associated with post-transplant mortality. Although prospective confirmation of our findings is necessary, compared with HT alone, CHLT recipients were older with higher FALD scores, but had similar survival overall and superior survival in patients with a FALD score ≥2.
Study context
- Population
- Adult Fontan patients (age ≥16 years at referral) referred for and undergoing HT or combined heart-liver transplant (CHLT)
- Participants
- 131 patients
- Exposure
- Combined heart-liver transplant vs heart transplant alone
- CHLTn = 40
- HTn = 91reference
Main finding
As reported in the abstract
Post-transplant survival (matched)
1-year survival
P = 0.097
5-year survival
P = 0.041
Observational data: associations, not effects.
Further findings
Survival in patients with FALD score ≥2 (subgroup) · 5 years
P = 0.019
1-year survival
P = 0.044
5-year survival
| Outcome | HR | P value |
|---|---|---|
| Survival, model adjusted for transplant decade and FALD score — CHLT vs HT | 0.33 | P = 0.044 |
| Survival, model adjusted for transplant decade and FALD score — FALD score 2 vs HT · worse survival | 14.6 | P = 0.015 |
| Survival, model adjusted for transplant decade and FALD score — FALD score 3 vs HT · worse survival | 22.2 | P = 0.007 |
| Survival, model adjusted for transplant decade and FALD score — FALD score 4 vs HT · worse survival | 27.8 | P = 0.011 |
Original publication
Clinical Outcomes of Adult Fontan-Associated Liver Disease and Combined Heart-Liver Transplantation. J Am Coll Cardiol. Published 6 June 2023. doi:10.1016/j.jacc.2023.03.421
Summarised from the published abstract; every number is checked against it