Valvular & structural heart diseaseCohort study
Clinical Outcomes of Redo Transcatheter Aortic Valve Replacement According to Computed Tomography Sizing
- Retrospective cohort study
- Median follow-up 368 days (Q1-Q3: 96-611 days)
Authors' conclusion
In patients undergoing redo-TAVR with preprocedural CT planning, a sizing strategy enabling selective TAV-2 oversizing relative to the LZ was associated with favorable outcomes without increased procedural complications.
Study context
- Population
- Consecutive patients undergoing redo-TAVR with preprocedural computed tomographic (CT) planning
- Participants
- 150 patients
- Exposure
- Landing zone (LZ)-concordant vs LZ-discordant TAV-2 sizing in redo-TAVR
Main finding
As reported in the abstract
Bioprosthetic valve failure · 1 year
Estimated rate of bioprosthetic valve failure, overall
8.7% (95% CI: 3.1%-14.2%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Independent predictors of bioprosthetic valve failure — LZ perimeter <62 mm vs LZ concordant | 4.19 (1.37–12.8) | P = 0.012 | |
| Independent predictors of bioprosthetic valve failure — TAV-2 size smaller than manufacturer sizing range for aortic annulus vs LZ concordant | 3.75 (1.25–11.2) | P = 0.018 | |
| 0.050.21520Hazard ratio (log scale) |
Transcatheter aortic valve (TAV-1) compression
- TAV-1 compression
- 97.3%
LZ-discordant TAV-2 sizes
- Patients receiving LZ-discordant TAV-2 sizes
- 52%
- Oversizing to the LZ
- 21.2% (15.8%-24.8%)
- Oversizing to the annulus
- 7.1% (3.1%-10.9%)
- mostly larger than recommended TAV-2
Device success · 30 days
- Device success
- 73.3%
Safety
Annular rupture
- Annular rupture events
- 0
Original publication
Clinical Outcomes of Redo Transcatheter Aortic Valve Replacement According to Computed Tomography Sizing. JACC Cardiovasc Interv. Published 27 October 2025. doi:10.1016/j.jcin.2025.08.034
Summarised from the published abstract; every number is checked against it