Cardio-oncology & otherCohort study
Clinical Outcomes of the Prospective Pakistan Registry of Echocardiographic Screening in Asymptomatic Pregnant Women
- Prospective registry
Authors' conclusion
Prospective Pakistan Registry of Echocardiographic Screening in Asymptomatic Pregnant Women is the first global study linking subclinical echocardiographic abnormalities in asymptomatic pregnant women to adverse fetomaternal outcomes. In a large cohort of asymptomatic pregnant women, an abnormal echocardiogram was found to be associated with 2- to 4 time as many adverse fetomaternal outcomes compared to a normal echocardiogram. Future studies are needed to evaluate optimal timing of screening, cost-effectiveness, and applicability of broad antenatal screening in higher-income countries.
Study context
- Population
- Asymptomatic pregnant women screened by echocardiography in Pakistan, February 2023 to April 2025patients enrolled in the registry, 489 pregnancies with structural heart disease (SHD) compared with 510 pregnancies without SHD · SHD 489 · non-SHD 510
- Participants
- 25,000 women
- Exposure
- pregnancies with SHD compared with pregnancies without SHD
- SHDn = 489
- non-SHDn = 510reference
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Fetal outcomes · significantly higher in the SHD cohort
P < 0.001
Overall fetomaternal outcomes · significantly higher in the SHD cohort
P < 0.001
| Outcome | adjusted OR (95% CI) | P value | |
|---|---|---|---|
| Adverse fetomaternal outcomes (adjusted) · SHD independently associated | 2.67 (1.93–3.70) | P < 0.001 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Mean maternal age · higher in SHD cohort
P = 0.011
Original publication
Summarised from the published abstract; every number is checked against it