Valvular & structural heart diseaseCohort study
Clinical Performance and Reproducibility of the LIRA Method for Transcatheter Aortic Valve Replacement (TAVR) in Bicuspid Anatomy
- Retrospective cohort study
- multicentre
- 6 centres
- blinded centralized core laboratory
Authors' conclusion
In this large multicenter cohort, the LIRA method demonstrated good reproducibility across centers and was associated with favorable procedural and clinical outcomes in BAV patients undergoing TAVR.
Study context
- Population
- Bicuspid aortic valve (BAV) patients undergoing TAVR sized with the LIRA (level of implantation at the raphe) method
- Participants
- 215 patients
- Outcome
- Clinical performance and reproducibility of the LIRA method for TAVR sizing (VARC-3 procedural and clinical outcomes)
- Follow-up
- 30 days and 1 year
Main finding
As reported in the abstract
- Prosthesis downsizing
- 74.4%
- Device success at 30 days
- 93%
- Moderate or greater paravalvular leak at 30 days
- 4.6%
- All-cause mortality at 1 year
- 5.7%
- Clinical efficacy at 1 year
- 92.8%
- Prosthesis sizing agreement (κ), 95% CI 0.74-0.96
- 0.85
- Perimeter concordance (intraclass correlation coefficient), 95% CI 0.63-0.85
- 0.76
Observational data: associations, not effects.
Safety
Adverse events at 30 days
- New permanent pacemaker implantation
- 10.7%
- Stroke
- 1.9%
Original publication
Clinical Performance and Reproducibility of the LIRA Method for TAVR in Bicuspid Anatomy. JACC Cardiovasc Interv. Published 28 September 2026. doi:10.1016/j.jcin.2026.06.018
Summarised from the published abstract; every number is checked against it