Acute cardiac care & resuscitation
Clinical Phenotypes of Cardiogenic Shock Survivors: Insights into Late Host Responses and Long-Term Outcomes
Primary result · 1-year mortalityResult — go to the resultAdjusted hazard ratio 2.83 95% CI 1.21–6.60Authors' conclusion
A phenotype with sustained inflammation, myocardial fibrosis, and endothelial dysfunction at ICU discharge was identified from readily available data and was independently associated with poor long-term outcomes in CS survivors.
Study context
- Population
- Cardiogenic shock survivors discharged alive from the intensive care unit (ICU)of 228 ICU patients with cardiogenic shock (CS)
- Participants
- 173 survivors
- Comparison
- Phenotype B vs Phenotype A at ICU discharge
- Primary endpoint
- Mortality
- Follow-up
- 1 year after ICU discharge
Methodological detailslatent class analysis, international, multicentre
- Latent class analysis
- International
- Multicentre
Primary result
1-year mortality
Adjusted hazard ratio
2.83
95% CI 1.21–6.60
P = 0.016
Phenotype Bvs Phenotype A
adjusted HR 2.83 (95% CI 1.21–6.60); P = 0.016
As reported in the abstract
- Higher 1-year mortality in Phenotype B vs A (Kaplan-Meier)
- P = 0.045
Secondary outcomes
- Phenotype B prevalence
- 38%
- Phenotype B prevalence: Phenotype B: more non-ischaemic CS and RV dysfunction on admission
Physical quality of life (SF-36 physical component score) · 3 months
- Significantly lower in Phenotype B
Original publication
Clinical Phenotypes of Cardiogenic Shock Survivors: Insights into Late Host Responses and Long-Term Outcomes. ESC Heart Fail. Published 4 December 2023. doi:10.
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