Cardio-oncology & otherCohort study
Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry
- Observational cohort study
- nationwide
- registry
Authors' conclusion
In a nationwide consecutive cohort of patients with left-sided IE, 40% had indications for surgery according to guidelines, but only half of these underwent surgery. Surgically treated patients had the highest survival but were a decade younger, had fewer comorbidities, and had less frequent IE caused by S aureus.
Study context
- Population
- Patients with left-sided infective endocarditis (IE), National Danish Endocarditis Studies (2016–2021); surgical indication = Class I indication (2015 European guidelines) or vegetation ≥10 mm
- Participants
- 3,017 patients
- Exposure
- Surgery vs Conservative vs No indication
- Surgeryn = 662
- Conservativen = 655
- No indicationn = 1,700
- Outcome
- Mortality
- Follow-up
- 1 year
Main finding
As reported in the abstract
1-year mortality
P < 0.001
Observational data: associations, not effects.
Further findings
In-hospital mortality · across the three groups
P < 0.001
Reason for withholding surgery
- High surgical risk (most reported reason)
- 22.8%
Original publication
Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry. Circulation. Published 21 August 2025. doi:10.1161/circulationaha.125.074608
Summarised from the published abstract; every number is checked against it