Cardiometabolic & kidneyCohort study
Clinical trajectory and disease progression in patients with cardio-renal-metabolic syndrome: the CaReMap observational study
- observational cohort study
- population-based
- real-world setting
Authors' conclusion
In this population-based Italian cohort, DM, HF, and CKD define distinct diagnostic trajectories with substantial competing risk of death. These findings provide real-world estimates of transition patterns and absolute risks that may inform risk stratification and integrated care pathways.
Study context
- Population
- Adults with established cardio-renal-metabolic (CRM)-related conditions (diabetes mellitus (DM), heart failure (HF) or chronic kidney disease (CKD)) in an Italian Regional Epidemiological Repository, 2017 to 2022adults with established CRM-related conditions · incident 31.8% · prevalent 68.2%
- Participants
- 71,694 adults
- Exposure
- Incident patients vs Prevalent patients
Main finding
As reported in the abstract
Probability of developing an additional diagnosis, incident patients with HF · 6 years
Incident patients
60.4%
Observational data: associations, not effects.
Further findings
- Probability of death before a new diagnosis, incident patients with CKD · 6 years
- 43.3%
- Cumulative incidence of further diagnoses, prevalent patients in the DM&HF group · 6 years
- 47.1%
- Probability of death before a new diagnosis, incident patients with CKD: CKD showed the highest probability of death before a new diagnosis
- Cumulative incidence of further diagnoses, prevalent patients in the DM&HF group: DM&HF group showed the highest cumulative incidence of further diagnoses
Overall survival
- Across both incident and prevalent cohorts, HF and CKD patients experienced the steepest decline in overall survival
Original publication
Clinical trajectory and disease progression in patients with cardio-renal-metabolic syndrome: the CaReMap observational study. Eur J Heart Fail. Published 9 October 2026. doi:10.1093/ejhf/xuag308
Summarised from the published abstract; every number is checked against it