Coronary disease & ACSMeta-analysis
Clonal haematopoiesis and outcomes after acute coronary syndrome: a systematic review and meta-analysis
- systematic review and meta-analysis of observational studies
Authors' conclusion
CHIP is associated with increased mortality following ACS across a broad range of clinical settings, suggesting it is a marker of adverse post-ACS risk. These findings highlight the need for adequately powered prospective studies with standardised CHIP ascertainment to determine whether CHIP represents a feasible biomarker or modifiable therapeutic target.
Study context
- Population
- Patients after acute coronary syndrome (ACS), from low-risk ACS to cardiogenic shockstudies included
- Participants
- Eight patients
- Comparison
- outcomes after ACS in patients with and without clonal haematopoiesis of indeterminate potential (CHIP)
- Outcome
- All-cause mortality
Pooled result
As reported in the abstract
Pooled hazard ratio
1.61
95% CI 1.36–1.92
CHIP vs without CHIP
pooled HR 1.61 (95% CI 1.36–1.92)
Further pooled results
Mutation-specific analyses (exploratory)
- Underpowered but suggested a more consistent association between TET2 mutations and adverse events
Study-level analyses of smoking prevalence (exploratory)
- Differences in smoking prevalence between CHIP carriers and non-carriers may contribute to variability in association strength
- no formal interaction testing was possible
Original publication
Clonal haematopoiesis and outcomes after acute coronary syndrome: a systematic review and meta-analysis. ESC Heart Fail. Published 6 July 2026. doi:10.1093/eschf/xvag191
Summarised from the published abstract; every number is checked against it