Heart failure & cardiomyopathies
Clonal Haematopoiesis is Associated with Major Adverse Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy
Main finding · MACE in HCM with sarcomeric germline mutationsResult — go to the resultAdjusted hazard ratio 6.89 95% CI 1.78–26.6Authors' conclusion
These results indicate that CH in patients with HCM is associated with worse clinical outcomes.
Study context
- Population
- Patients with hypertrophic cardiomyopathy (HCM) with available biospecimens, Peter Munk Cardiac Centre Cardiovascular Biobank
- Participants
- 799 patients
- Exposure
- Clonal haematopoiesis (CH) vs no CH
- CHn = 183
- Outcome
- MACE:
- Appropriate ICD shock
- Stroke
- Cardiac arrest
- Orthotopic heart transplant
- Death
Methodological detailsbiobank
- Biobank
Main finding
MACE in HCM with sarcomeric germline mutations
Adjusted hazard ratio
6.89
95% CI 1.78–26.6
P = 0.005
CHvs No CH
adjusted HR 6.89 (95% CI 1.78–26.6); P = 0.005
As reported in the abstract
Observational data: associations, not effects.
Further findings
Major adverse cardiovascular events (MACE) with DNMT3A, TET2 and ASXL1 mutations
| Adjusted HR (95% CI) | P value | ||
|---|---|---|---|
| CH (DNMT3A, TET2, ASXL1) | 5.76 (1.51–21.94) | P = 0.010 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
- Prevalence of CH in HCM with sarcomeric germline mutations
- 22.9% · 183
Symptoms, fibrosis, cytokines and troponin I
- CH: more symptomatic and higher fibrosis burden than no CH
- IL-1ra, IL-6, IL-17F, TGFα, CCL21, CCL1, CCL8, CCL17 and troponin I upregulated in gene-positive HCM with CH
Original publication
Clonal Haematopoiesis is Associated with Major Adverse Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy. Eur J Heart Fail. Published 1 August 2024. doi:10.
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