Arrhythmias & electrophysiologyCohort study
Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias
- Prospective cohort study
- UK Biobank
- multivariable-adjusted Cox regression
Authors' conclusion
CHIP may represent a novel risk factor for incident arrhythmias
Study context
- Population
- UK Biobank participants without prevalent arrhythmias
- Participants
- 410,702 participants
- Exposure
- Clonal haematopoiesis of indeterminate potential (CHIP) vs no CHIP
- Any CHIPn = 13,892
- Large CHIPn = 9,191
- Outcome
- Co-primary: incident supraventricular arrhythmias, bradyarrhythmias and ventricular arrhythmias
Main finding
As reported in the abstract
Incident arrhythmias (co-primary outcomes)
Each group vs no CHIPHazard ratio (95% CI)P value
Any CHIPsupraventricular arrhythmias
1.11(1.04–1.18)
P = 0.001Large CHIPsupraventricular arrhythmias
1.13(1.05–1.22)
P = 0.001Any CHIPbradyarrhythmias
1.09(1.01–1.19)
P = 0.031Large CHIPbradyarrhythmias
1.13(1.03–1.25)
P = 0.011Any CHIPventricular arrhythmias
1.16(1.00–1.34)
P = 0.049Large CHIPventricular arrhythmias
1.22(1.03–1.45)
P = 0.021Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Top quintile of myocardial fibrosis by CMR (T1) | 1.31 (1.07–1.59) | P = 0.009 | |
| 0.512Odds ratio (log scale) |
Arrhythmia subtypes, incl. cardiac arrest
- Associations heterogeneous across arrhythmia subtypes and strongest for cardiac arrest
Arrhythmias by CHIP driver gene
- Increased risk of arrhythmias across driver genes other than DNMT3A
Original publication
Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias. Eur Heart J. Published 11 November 2023. doi:10.1093/eurheartj/ehad670
Summarised from the published abstract; every number is checked against it