Prevention & lipidsCohort study
Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women
- Prospective cohort study
Authors' conclusion
In an older female cohort, key CHIP subtypes (TET2, ASXL1, and JAK2) were associated with incident CVD, with associations that appeared to differ by CVD outcome.
Study context
- Population
- Older women in the Women's Health Initiative Long Life Study (median age 80 years)
- Participants
- 6,677 women
- Exposure
- Clonal hematopoiesis of indeterminate potential (CHIP) vs no CHIP
- Composite CHIPn = 2,176
- Outcome
- Incident CHD
- Follow-up
- Median 10.1 years
Main finding
As reported in the abstract
Each group vs no CHIPAdjusted hazard ratio (95% CI)P value
TET2 CHIP
1.36(1.05–1.77)
P = 0.02Composite CHIP
1.07(0.89–1.28)
P = 0.49Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| HFpEF (TET2 CHIP) | 1.40 (1.03–1.90) | P = 0.03 | |
| HFrEF (ASXL1 CHIP) | 3.16 (1.53–6.55) | P = 0.002 | |
| Ischemic stroke, VTE, CV death (JAK2 CHIP) — JAK2 CHIP vs No CHIP · ischemic stroke | 2.49 (1.17–5.30) | P = 0.02 | |
| Ischemic stroke, VTE, CV death (JAK2 CHIP) — JAK2 CHIP vs No CHIP · VTE | 2.71 (1.11–6.65) | P = 0.03 | |
| Ischemic stroke, VTE, CV death (JAK2 CHIP) — JAK2 CHIP vs No CHIP · CV death | 2.62 (1.68–4.11) | P < 0.001 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Other outcomes, composite or DNMT3A CHIP
- No other significant associations for composite or DNMT3A CHIP
Original publication
Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women. J Am Coll Cardiol. Published 27 August 2025. doi:10.1016/j.jacc.2025.07.058
Summarised from the published abstract; every number is checked against it