Congenital heart diseaseCohort study
Coarctation of Aorta With Tricuspid Aortic Valve Is Not Associated With Ascending Aortic Aneurysm
- Matched cohort study
Authors' conclusion
These findings suggest that BAV (and not COA) was associated with ascending thoracic aorta dimensions, and that patients with COA+TAV were not at a greater risk of developing ascending aortic aneurysms as compared with patients without SHD.
Study context
- Population
- Patients with coarctation of aorta, matched to patients with isolated bicuspid aortic valve (BAV) and without structural heart diseaseCoarctation of aorta (COA) 867 matched 1:1:1
- Participants
- 304 / 563 / 867 / 867
- Exposure
- COA vs isolated BAV vs no structural heart disease
- COA+BAVn = 304
- COA+tricuspid aortic valve (TAV)n = 563
- BAVn = 867
- no-SHDn = 867reference
- Outcome
- Aortic dimensions (aortic root and mid ascending aorta diameter)
- Follow-up
- Baseline and 3, 5 and 7 years
Main finding
As reported in the abstract
Aortic diameters vs no-SHD
| Group | Aortic root diameter | Mid ascending aorta diameter |
|---|---|---|
| COA+BAV | 37 mm [Q1-Q3: 30-43 mm] | 34 mm [Q1-Q3: 29-40 mm] |
| BAV | 37 mm [Q1-Q3: 30-42 mm] | 35 mm [Q1-Q3: 30-40 mm] |
| no-SHD | 32 mm [Q1-Q3: 27-35 mm] | 28 mm [Q1-Q3: 24-31 mm] |
- COA+BAV vs no-SHD: P < 0.001 — aortic root diameter
- COA+BAV vs no-SHD: P = 0.008 — mid ascending aorta diameter
- BAV vs no-SHD: P < 0.001 — aortic root diameter
- BAV vs no-SHD: P < 0.001 — mid ascending aorta diameter
Observational data: associations, not effects.
Safety
Acute aortic complications
- Low risk in all groups
Original publication
Coarctation of Aorta With Tricuspid Aortic Valve Is Not Associated With Ascending Aortic Aneurysm. J Am Coll Cardiol. Published 26 March 2024. doi:10.1016/j.jacc.2024.01.026
Summarised from the published abstract; every number is checked against it