Arrhythmias & electrophysiologyCohort study
Coexistence of atrial fibrillation and metabolic dysfunction-associated steatotic liver disease as a high-risk overlap for incident heart failure in older adults
- Retrospective cohort study
- nationwide database (Korean National Health Insurance Service)
Authors' conclusion
Coexistence of AFib and MASLD identifies a high-risk overlap state for incident HF in older adults.
Study context
- Population
- Adults aged ≥60 years with AF diagnosed 2002–2010, Korean National Health Insurance Service database
- Participants
- 7,543 adults
- Exposure
- MASLD and subtypes vs no MASLD in older adults with AF
- MASLDn = 3,168
- MetALDn = 259
- Alcoholic liver disease (ALD)n = 159
- Outcome
- Incident HF
- Follow-up
- From 1 January 2011 to 31 December 2019
Main finding
As reported in the abstract
Subdistribution HRP value
MASLD
1.22(95% CI 1.10–1.35)
P < 0.001MetALD
1.36(CI 1.05–1.76)
P = 0.019ALD
1.42(CI 1.03–1.97)
P = 0.034Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic splines): Fatty liver index (FLI) and daily alcohol consumption
- Significant dose-response relationships of FLI and daily alcohol consumption with increased heart failure (HF) risk
Original publication
Coexistence of atrial fibrillation and metabolic dysfunction-associated steatotic liver disease as a high-risk overlap for incident heart failure in older adults. Eur J Heart Fail. Published 10 February 2026. doi:10.1093/ejhf/xuag036
Summarised from the published abstract; every number is checked against it