Coronary disease & ACSResearch article
Combined Anatomic and Functional Testing Identifies Patients With Obstructive Coronary Artery Disease Who Benefit From Revascularization
- Two trials enrolling stable patients with new-onset chest pain suggestive of obstructive coronary artery disease, the ISCHEMIA and the Dan-NICAD trials, were analyzed
- Test-guided revascularization blinded to nuclear myocardial perfusion imaging (nMPI)
- patients with initially abnormal nMPI were reassessed after 12 months
Authors' conclusion
In patients with single-vessel coronary artery disease, nMPI may identify patients more likely to experience improved symptoms from revascularization, potentially reflecting enhanced myocardial perfusion.
Study context
- Population
- Stable patients with new-onset chest pain suggestive of obstructive coronary artery disease, with single-vessel coronary artery disease, who underwent nuclear myocardial perfusion imaging (nMPI)patients eligible
- Participants
- 584 patients
- Comparison
- Changes in health status outcomes following revascularization by the extent of myocardial perfusion defects and improvement in myocardial perfusion
- summed difference score of 5≤10n = 149
- summed difference score ≥10n = 152
- Outcome
- Change in the Seattle Angina Questionnaire angina frequency score
Main finding
As reported in the abstract
summed difference score of 5≤10
16.4
mean change · SD 20.9
summed difference score ≥10
19.0
mean change · SD 24.1
No improvement in the Seattle Angina Questionnaire angina frequency score was demonstrated in patients with a summed difference score <
5
Further findings
Freedom from angina, by increase in hyperemic myocardial blood flow at follow-up
- Increase in hyperemic myocardial blood flow at follow-up, odds ratio (95% CI) for freedom from angina
- 2.89 [95% CI, 1.04-8.70]
- multivariable logistic regression analysis (n=91)
Original publication
Combined Anatomic and Functional Testing Identifies Patients With Obstructive Coronary Artery Disease Who Benefit From Revascularization. Circ Cardiovasc Imaging. Published 20 March 2026. doi:10.1161/circimaging.125.019267
Summarised from the published abstract; every number is checked against it