Cohort study
Combined Effects of Clonal Hematopoiesis and Carotid Stenosis on Cardiovascular Mortality
- Prospective cohort study
Authors' conclusion
CH status in combination with the extent of carotid atherosclerosis jointly predict long-term mortality.
Study context
- Population
- Patients with asymptomatic carotid atherosclerosis evaluated by duplex sonographymedian age 69.2 years
- Participants
- 968 patients
- Exposure
- CH vs no CH
- CHn = 133
- Outcome
- CV death
Main finding
As reported in the abstract
Hazard ratio
1.50
95% CI 1.12–2.00
P = 0.007
CH vs No CH
HR 1.50 (95% CI 1.12–2.00); P = 0.007
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (95% CI) | P value | |
|---|---|---|---|
| CV mortality, >50% carotid stenosis with concomitant CH | 1.60 (1.08–2.38) | P = 0.020 | |
| 0.512Adjusted hazard ratio (log scale) |
- CH prevalence
- 13.7% · 133 of 133
CH prevalence
- Prevalence increasing at advanced age
CV death by age and inflammatory status
- Effect of CH more pronounced in older patients and independent of hs-CRP
Original publication
Combined Effects of Clonal Hematopoiesis and Carotid Stenosis on Cardiovascular Mortality. J Am Coll Cardiol. Published 7 May 2024. doi:10.1016/j.jacc.2024.02.043
Summarised from the published abstract; every number is checked against it