Heart failure & cardiomyopathiesRandomised controlled trial
Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial
- Randomised controlled trial
- multicentre
Authors' conclusion
In conclusion, 1 year of combined endurance and resistance ET did not result in a significantly better modified Packer score, but it did result in improvements in important clinical parameters, such as peak V ̇ O 2 and NYHA class, as compared to UC.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) (mean age 70 years)randomized 1:1
- Participants
- 322 patients
- Comparison
- Combined endurance and resistance exercise training (ET) vs usual care
- Primary endpoint
- Modified Packer score (all-cause mortality, hospitalizations potentially related to HF or exercise, changes in peak VO2, E/e', New York Heart Association (NYHA) class and global self-assessment)
- Follow-up
- 12 months
Primary result
Modified Packer score
Kendall's tau-b
−0.073
P = 0.17
By group
ET
33 (20.5%)
Improved · Worsened 69 (42.9%)
Usual care (UC)
13 (8.1%)
Improved · Worsened 71 (44.1%)
As reported in the abstract
Secondary outcomes
| Outcome | mean difference (ml kg-1 min-1) (95% CI) | |
|---|---|---|
| Change in peak VO2 | 1.3 (0.4–2.1) | |
| −10123Difference, ml kg-1 min-1 (linear scale) |
| Outcome | OR (95% CI) | |
|---|---|---|
| NYHA class | 7.77 (3.73–16.21) | |
| 0.050.21520Odds ratio (log scale) |
Change in E/e', change in global self-assessment (GSA), time to CV hospitalization, all-cause mortality
- No significant between-group differences
Original publication
Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial. Nat Med. Published 2 January 2025. doi:10.1038/s41591-024-03342-7
Summarised from the published abstract; every number is checked against it