Valvular & structural heart diseaseCohort study
Combined transcatheter mitral and tricuspid edge-to-edge repair or tricuspid edge-to-edge repair alone in moderate mitral regurgitation: a propensity-matched analysis
- Retrospective registry analysis
- propensity-score matched
- EuroTR registry
Authors' conclusion
Moderate MR predicts impaired prognosis in patients undergoing T-TEER for treatment of severe TR. Concomitant M-TEER is associated with improved survival and functional outcomes in this population with multivalve disease.
Study context
- Population
- Patients with severe tricuspid regurgitation (TR) treated with tricuspid TEER (T-TEER), EuroTR registry 2016–25217 matched with mitral TEER (M-TEER)
- Participants
- 3,100 patients
- Exposure
- Combined T-TEER + M-TEER vs T-TEER alone with untreated moderate mitral regurgitation (MR)
- Outcome
- All-cause mortality
- Follow-up
- 2 years
Main finding
All-cause survival
Hazard ratio
0.46
P < 0.0001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR | P value |
|---|---|---|
| TR reduction · −1.9 vs −1.6 grades | P = 0.001 | |
| 2-year mortality, moderate MR vs no moderate MR (full cohort) · multivariable analysis; unadjusted 23% vs 37%, p<0.0001 | 1.81 | P = 0.005 |
- All-cause survival: survival 87% vs 76% at 1 year, higher in the combined treatment group
New York Heart Association (NYHA) class, 6MWD · follow-up
- Better NYHA improvement and increased 6MWD with concomitant M-TEER
Original publication
Combined transcatheter mitral and tricuspid edge-to-edge repair or tricuspid edge-to-edge repair alone in moderate mitral regurgitation: a propensity-matched analysis. Eur Heart J. Published 24 April 2026. doi:10.1093/eurheartj/ehag186
Summarised from the published abstract; every number is checked against it