Heart failure & cardiomyopathiesSecondary analysis
Combining Loop and Thiazide Diuretics Across the Left Ventricular Ejection Fraction Spectrum
- Secondary analysis of the CLOROTIC randomised trial
- post hoc
- double-blind
- placebo-controlled
Authors' conclusion
Adding HCTZ to intravenous furosemide seems to be effective strategy for improving diuretic response in AHF without treatment effect modification according to baseline LVEF.
Study context
- Population
- Patients with acute HF, by left ventricular ejection fraction (LVEF) (>40% vs ≤40%)166 LVEF >40%, 64 LVEF ≤40%
- Participants
- 230 patients
- Comparison
- Hydrochlorothiazide (HCTZ) vs placebo added to IV furosemide, by LVEF
- Primary endpoint
- Influence of LVEF on primary and secondary outcomes
Primary result
As reported in the abstract
Weight loss, diuretic response and 24-hour diuresis by LVEF category
No significant differences according to LVEF category (cutoffs 40% and 50%) or LVEF as a continuous variable
all P values were insignificant
Secondary outcomes
Mortality and rehospitalizations, by LVEF group
- No significant differences with HCTZ among the 2 LVEF groups
- all P values were insignificant
Safety
Impaired renal function, hyponatremia, hypokalemia, by LVEF group
- No significant differences with HCTZ among the 2 LVEF groups
- all P values were insignificant
Original publication
Combining Loop and Thiazide Diuretics Across the Left Ventricular Ejection Fraction Spectrum. JACC Heart Fail. Published 26 June 2024. doi:10.1016/j.jchf.2024.05.006
Summarised from the published abstract; every number is checked against it