Heart failure & cardiomyopathies
Common Variants on FGD5 Increase Hazard of Mortality or Rehospitalization in Patients With Heart Failure From the ASCEND-HF Trial
Authors' conclusion
In this multiethnic genome-wide association study of ASCEND-HF, single-nucleotide polymorphisms in FGD5 were associated with increased risk of death or rehospitalization.
Study context
- Population
- Patients hospitalized with HF in the ASCEND-HF trial
- Participants
- 2,173 vs 507
- Comparison
- FGD5 common variants and death or HF rehospitalization
- European ancestryn = 2,173
- African ancestryn = 507
- Outcome
- Death or HF rehospitalization, FGD5 variants (rs2342882 and rs35850039)
- Follow-up
- 180 days
Methodological detailsgenetic substudy of the ASCEND-HF randomised trial, multiethnic, Cox models adjusted for 11 a priori predictors and 5 genetic principal components, significance threshold P<5×10-8
- Genetic substudy of the ASCEND-HF randomised trial
- Multiethnic
- Cox models adjusted for 11 a priori predictors and 5 genetic principal components
- Significance threshold P<5×10-8
Pooled result
As reported in the abstract
Hazard ratio
1.38
P = 2.42×10–6
European ancestry · European Americans
Hazard ratio
1.51
P = 4.43×10–3
African ancestry
Hazard ratio
1.41
P = 4.25×10–8
Meta-analysis · transethnic meta-analysis
Further pooled results
| Outcome | HR | P value |
|---|---|---|
| Death or HF rehospitalization, rs748431 (previous GWAS hit in FGD5) | 1.20 | meta P<0.01 |
| Death or HF rehospitalization, FGD5 variants, censoring at 30 days | 1.39 | P = 1.59×10-5 |
Sensitivity analysis: mediation via CAD or nesiritide treatment
- Association did not appear to operate via CAD or nesiritide treatment
- P > 0.05
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Common Variants on FGD5 Increase Hazard of Mortality or Rehospitalization in Patients With Heart Failure From the ASCEND-HF Trial. Circ Heart Fail. Published 26 July 2023. doi:10.
Summarised from the published abstract; every number is checked against it