Arrhythmias & electrophysiologyResearch article
Comorbidity phenotypes, prognostic implications, and Atrial fibrillation Better Care pathway effectiveness in patients with early-onset atrial fibrillation: A latent class analysis from the Tianjin Atrial Fibrillation Project
- latent class analysis
- Tianjin Atrial Fibrillation Project
Authors' conclusion
3 heterogeneous comorbidity-based phenotype clusters were identified in patients with early-onset AF, associated with different treatment and prognosis. Full ABC pathway adherence improved prognosis in younger patients with AF, regardless of their comorbidity phenotypes.
Study context
- Population
- Patients with early-onset atrial fibrillation (AF) aged 18–45 yearspatients with early-onset AF (mean age, 38.68 ± 5.82 years, 781 [21.9%] female)
- Participants
- 3,573 patients
- Comparison
- Comorbidity phenotype clusters 2 and 3 compared with cluster 1; ABC pathway adherence
- cluster 1n = 1,897reference
- cluster 2n = 1,037
- cluster 3n = 639
- Outcome
- Composite of:
- All-cause death
- Major adverse cardiovascular events
- Follow-up
- Median 1408 days (interquartile range, 496-2532)
Main finding
As reported in the abstract
Each group vs cluster 1Hazard ratio (95% CI)P value
cluster 2
1.94(1.56–2.42)
P < 0.001cluster 3
2.63(2.15–3.20)
P < 0.001Further findings
Primary outcome with ABC pathway adherence
- ABC pathway adherence (n = 1186 [33.2%] patients), HR for primary outcome overall, 95% Cl 0.40-0.56, P < .001
- 0.47
- Similar benefits across different comorbidity phenotypes
- Pint = 0.097
- comparator for the ABC adherence HR not stated
Original publication
Comorbidity phenotypes, prognostic implications, and Atrial fibrillation Better Care pathway effectiveness in patients with early-onset atrial fibrillation: A latent class analysis from the Tianjin Atrial Fibrillation Project. Heart Rhythm. Published 3 August 2026. doi:10.1016/j.hrthm.2026.07.041
Summarised from the published abstract; every number is checked against it