Arrhythmias & electrophysiologyResearch article
Comparative 1-year outcomes of pentaspline versus circular array pulsed field ablation for pulmonary vein isolation with adjunctive atrial lines
- Consecutive patients undergoing fluoroscopy-guided pulmonary vein isolation (PVI) using either a pentaspline or circular pulsed field ablation (PFA) catheter
Authors' conclusion
Pentaspline and circular PFA catheters demonstrate comparable safety, procedural performance, and 1-year clinical efficacy for PVI and LARA. These findings support the feasibility of comprehensive PFA-based atrial ablation strategies in patients with persistent atrial fibrillation and enlarged left atria.
Study context
- Population
- Patients with atrial fibrillation (AF) undergoing PVI with pulsed field ablation, with LARA in patients with persistent AF and left atrial enlargement (LA area >20 cm²), November 2023 to November 2024100 patients per group · Pentaspline 100 · Circular 100
- Participants
- 200 patients
- Comparison
- Pentaspline PFA catheter vs Circular PFA catheter
- Pentaspline PFA cathetern = 100
- Circular PFA cathetern = 100
- Outcome
- Freedom from atrial arrhythmia after a 3-month blanking period
- Follow-up
- 1 year
Main finding
As reported in the abstract
log-rank P = .90
Further findings
LARA performed
Median procedure time · comparable
P = 0.06
Fluoroscopy time · comparable
P = 0.203
Acute PVI and bidirectional block of all additional lines
- Achieved in all cases
- 100%
Safety
Overall complication rates
Overall complication rates
- Low and similar
Original publication
Comparative 1-year outcomes of pentaspline versus circular array pulsed field ablation for pulmonary vein isolation with adjunctive atrial lines. Heart Rhythm. Published 14 April 2026. doi:10.1016/j.hrthm.2026.03.1914
Summarised from the published abstract; every number is checked against it