Prevention & lipidsCohort study
Comparative Discrimination of Life’s Simple 7 and Life’s Essential 8 to Stratify Cardiovascular Risk: Is the Added Complexity Worth It?
- Prospective cohort study
Authors' conclusion
Both LS7 and LE8 were associated with incident CVD, with discrimination of the 2 indices practically indistinguishable.
Study context
- Population
- Black and White participants free of baseline cardiovascular disease (CVD) in the REGARDS study, enrolled 2003 to 2007median follow-up 13 years
- Participants
- 11,609 participants
- Exposure
- LS7 vs LE8 for CVD risk discrimination
- Outcome
- Discrimination of incident CVD (CHD or stroke), difference in c-statistic
- Follow-up
- 10-year risk
Main finding
As reported in the abstract
Age-race-sex adjusted c-statistic for incident CVD
LS7
0.691
c-statistic · 95% CI 0.667–0.705
LE8
0.695
c-statistic · 95% CI 0.681–0.709
P for difference, 0.12
Observational data: associations, not effects.
Further findings
| Outcome | LS7 | LE8 |
|---|---|---|
| 10-year CVD risk by score position | 8.4% (95% CI 7.2%–9.8%) | 8.5% (95% CI 7.1%–10.1%) |
| Cluster | 2013 participants with LS7 score of 7, 35.8th percentile | 1457 participants with LE8 score of 60±2.5, 39.4th percentile |
10-year CVD risk by score position
- 10-year risk ≈5% around the 99th percentile of scores and 20% (4× higher) around the first percentile, for both LS7 and LE8
- 10-year risk nearly identical for individuals at the same relative position in score distribution
Original publication
Comparative Discrimination of Life’s Simple 7 and Life’s Essential 8 to Stratify Cardiovascular Risk: Is the Added Complexity Worth It? Circulation. Published 13 October 2023. doi:10.1161/circulationaha.123.065472
Summarised from the published abstract; every number is checked against it