Aortic & peripheral vascular disease
Comparative Efficacy of Endovascular Revascularization Modalities for Symptomatic Infrapopliteal Peripheral Artery Disease: A Network Meta-Analysis
Authors' conclusion
Compared with PTA, DCBs and DES demonstrated higher primary patency and lower binary restenosis, and DCBs reduced late lumen loss, percentage in-lesion diameter stenosis, and clinically driven target lesion revascularization.
Study context
- Population
- Patients with symptomatic infrapopliteal peripheral artery disease (PAD)
- Participants
- 1,102 / 284 / 903 / 695
- Comparison
- Percutaneous transluminal angioplasty (PTA) vs bare-metal stents (BMS) vs DCB vs drug-eluting stents (DES)
- PTAn = 1,102reference
- BMSn = 284
- Drug-coated balloons (DCBs)n = 903
- DESn = 695
Methodological detailsrandom-effects
- Random-effects
Pooled result
As reported in the abstract
Primary patency
Each group vs PTAOdds ratio (95% CI)P value
DCBs
2.66(1.52–4.64)
P = 0.001DES
2.41(1.23–4.73)
P = 0.01Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Target lesion binary (>50%) restenosis — DCBs vs PTA | 0.40 (0.21–0.77) | P = 0.006 | |
| Target lesion binary (>50%) restenosis — DES vs PTA | 0.28 (0.13–0.62) | P = 0.002 | |
| Clinically driven target lesion revascularization | 0.47 (0.29–0.76) | P = 0.002 | |
| Complete wound healing · decreased odds with BMS | 0.41 (0.20–0.85) | P = 0.02 | |
| 0.10.31310Odds ratio (log scale) |
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| In-lesion diameter stenosis | −10.04 (−19.20 to −0.88) | P = 0.03 | |
| −20−10010Difference (linear scale) |
| Outcome | MD (95% CI) | P value |
|---|---|---|
| Late lumen loss · lowered with DCBs | 0.34 (−0.63 to −0.05) | P = 0.02 |
Amputation, mortality
- No significant differences across the 4 groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparative Efficacy of Endovascular Revascularization Modalities for Symptomatic Infrapopliteal Peripheral Artery Disease: A Network Meta-Analysis. JACC Cardiovasc Interv. Published 13 July 2026. doi:10.
Summarised from the published abstract; every number is checked against it