Aortic & peripheral vascular diseaseMeta-analysis
Comparative Efficacy of Endovascular Revascularization Modalities for Symptomatic Infrapopliteal Peripheral Artery Disease
- Systematic review and meta-analysis of randomised trials
- random-effects
Authors' conclusion
Compared with PTA, DCBs and DES demonstrated higher primary patency and lower binary restenosis, and DCBs reduced late lumen loss, percentage in-lesion diameter stenosis, and clinically driven target lesion revascularization.
Study context
- Population
- Patients with symptomatic infrapopliteal peripheral artery disease (PAD)
- Participants
- 1,102 / 284 / 903 / 695
- Comparison
- Percutaneous transluminal angioplasty (PTA) vs bare-metal stents (BMS) vs DCB vs drug-eluting stents (DES)
- PTAn = 1,102reference
- BMSn = 284
- Drug-coated balloons (DCBs)n = 903
- DESn = 695
Pooled result
As reported in the abstract
Primary patency
Each group vs PTAOdds ratio (95% CI)P value
DCBs
2.66(1.52–4.64)
P = 0.001DES
2.41(1.23–4.73)
P = 0.01Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Target lesion binary (>50%) restenosis — DCBs vs PTA | 0.40 (0.21–0.77) | P = 0.006 | |
| Target lesion binary (>50%) restenosis — DES vs PTA | 0.28 (0.13–0.62) | P = 0.002 | |
| Clinically driven target lesion revascularization | 0.47 (0.29–0.76) | P = 0.002 | |
| Complete wound healing · decreased odds with BMS | 0.41 (0.20–0.85) | P = 0.02 | |
| 0.10.31310Odds ratio (log scale) |
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| In-lesion diameter stenosis | −10.04 (−19.20 to −0.88) | P = 0.03 | |
| −20−10010Difference (linear scale) |
| Outcome | MD (95% CI) | P value |
|---|---|---|
| Late lumen loss · lowered with DCBs | 0.34 (−0.63 to −0.05) | P = 0.02 |
Amputation, mortality
- No significant differences across the 4 groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparative Efficacy of Endovascular Revascularization Modalities for Symptomatic Infrapopliteal Peripheral Artery Disease. JACC Cardiovasc Interv. Published 13 July 2026. doi:10.1016/j.jcin.2026.02.046
Summarised from the published abstract; every number is checked against it