Heart failure & cardiomyopathiesMeta-analysis
Comparative Prognosis of Chagas and Other Cardiomyopathies
- Pooled analysis of the ATMOSPHERE, PARADIGM-HF and GALACTIC-HF randomised trials
- Cox models adjusted for baseline characteristics, patient setting, trial and other potential confounders
Authors' conclusion
Patients with Chagasic HFrEF have a distinct clinical course associated not only with excess mortality but also with an increased risk for stroke compared with other etiologies except for valvular and "other" etiologies.
Study context
- Population
- Patients with HF with reduced ejection fraction (HFrEF) in the ATMOSPHERE, PARADIGM-HF and GALACTIC-HF trials, by investigator-reported etiology
- Participants
- 23,647 patients
- Comparison
- Chagasic HFrEF vs ischemic and other nonischemic etiologies
- Ischemicn = 13,381reference
- Idiopathicn = 4,344
- Hypertensiven = 2,559
- Othern = 1,923
- Alcoholicn = 423
- Valvularn = 412
- Viraln = 297
- Chagasicn = 308
- Outcome
- Composite of:
- First HF hospitalization
- CV death
Pooled result
As reported in the abstract
Hazard ratio
1.65
95% CI 1.36–2.02
Chagasic vs Ischemic
HR 1.65 (95% CI 1.36–2.02)
Further pooled results
| Outcome | HR (95% CI) | |
|---|---|---|
| HF hospitalization · adjusted | 1.75 (1.36–2.25) | |
| CV death · adjusted | 1.86 (1.47–2.35) | |
| All-cause death · adjusted | 1.82 (1.47–2.25) | |
| Stroke · adjusted | 2.16 (1.20–3.88) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Comparative Prognosis of Chagas and Other Cardiomyopathies. J Am Coll Cardiol. Published 16 March 2026. doi:10.1016/j.jacc.2026.03.022
Summarised from the published abstract; every number is checked against it