Arrhythmias & electrophysiologyRandomised controlled trial
Comparing simultaneous hybrid ablation with stand-alone thoracoscopic surgical ablation for the treatment of non-paroxysmal atrial fibrillation: a prospective randomized controlled trial
- Randomised controlled trial
- 1:1 randomisation
Authors' conclusion
In patients with PerAF and enlarged left atrium or LSPAF, HA achieved better freedom from AF after 1 year of follow-up compared with thoracoscopic SA.
Study context
- Population
- Patients with persistent atrial fibrillation (AF) and enlarged left atrium or long-standing persistent AF
- Participants
- 100 patients
- Comparison
- Hybrid ablation vs thoracoscopic surgical ablation
- Primary endpoint
- Freedom from any AF recurrence off antiarrhythmic drugs (7-day ECG monitoring)
- Follow-up
- 12 months after operation
Primary result
Freedom from AF off AADs · 12 months
Odds ratio
2.955
95% CI 1.275–6.848
P = 0.014
Events by treatment group
HA vs SA
OR 2.955 (95% CI 1.275–6.848); P = 0.014
As reported in the abstract
Further findings
AF burden · 12 months after operation
P = 0.048
Mean difference, mm
| Outcome | HA | SA | P value |
|---|---|---|---|
| Change in left atrial diameter · 12 months after operation | −5.53 (SD 4.97) | −3.27 (SD 5.20) | P = 0.037 |
Original publication
Comparing simultaneous hybrid ablation with stand-alone thoracoscopic surgical ablation for the treatment of non-paroxysmal atrial fibrillation: a prospective randomized controlled trial. Europace. Published 3 September 2024. doi:10.1093/europace/euae226
Summarised from the published abstract; every number is checked against it