Valvular & structural heart diseaseRandomised controlled trial
Comparison between three single-dose cardioplegic solutions in myocardial protection: Cardioplegia Trial – a double-blind randomised clinical trial
- Double-blind randomised controlled trial
- Tertiary hospital in southern Brazil
Authors' conclusion
The three cardioplegic strategies showed comparable biochemical profiles of myocardial injury. DN was associated with lower early troponin release and reduced transfusion requirements, while HTK produced transient electrolyte shifts.
Study context
- Population
- Adults undergoing elective valve or coronary artery bypass surgery with cardiopulmonary bypassadults randomised
- Participants
- 99 adults
- Comparison
- Myocardial protection afforded by three single-dose cardioplegic solutions - Custodiol (HTK), del Nido (DN) and modified del Nido (MDN)
- Primary endpoint
- High-sensitivity cardiac troponin T (hs-cTnT)
- Follow-up
- 0, 2, 12 and 24 hours postoperatively
Primary result
As reported in the abstract
DN was associated with significantly lower High-sensitivity cardiac troponin T (hs-cTnT) at 2 hours
p=0.023
Further findings
Myocardial protection, clinical and laboratory outcomes
- All solutions provided effective myocardial protection, with similar clinical and laboratory outcomes
Intraoperative transfusions
- Fewer intraoperative transfusions with DN
- P = 0.008
Postoperative sodium and potassium levels
- Lower postoperative sodium with HTK
- P = 0.049
- Lower postoperative potassium with HTK
- P = 0.002
Survival and major postoperative outcomes, including vasoactive or mechanical support
- Similar across groups
Original publication
Comparison between three single-dose cardioplegic solutions in myocardial protection: Cardioplegia Trial – a double-blind randomised clinical trial. Heart. Published 28 May 2026. doi:10.1136/heartjnl-2025-327683
Summarised from the published abstract; every number is checked against it