Arrhythmias & electrophysiology
Comparison of cerebral safety after atrial fibrillation using pulsed field and thermal ablation: Results of the neurological assessment subgroup in the ADVENT trial
Authors' conclusion
Incidence of SCE/SCL after ablation in the NAS was low.
Study context
- Population
- Patients with paroxysmal atrial fibrillation (AF) undergoing ablation, with brain magnetic resonance imaging (MRI) 12–48 hours after ablation
- Participants
- 77 patients71 analysable scans
- Comparison
- Pulsed field ablation (PFA) vs thermal ablation
- PFAn = 34
- Thermal ablationn = 37reference
- Primary endpoint
- SCE/SCL on postprocedural brain MRI
- Follow-up
- 12-48 hours after ablation
Methodological detailsneurological assessment subgroup, blinded core laboratory MRI review, 6 centres
- Neurological assessment subgroup
- Blinded core laboratory MRI review
- 6 centres
Primary result
As reported in the abstract
SCE/SCL confirmed by blinded core laboratory
PFA
3
events
Thermal ablation
0
events
Safety
| Outcome | PFA | Thermal ablation |
|---|---|---|
| Neurological safety events in the whole ADVENT study (none in NAS)Neither part of the NAS | ||
| TIA | 1 | — not stated in the abstract |
| Stroke | — not stated in the abstract | 1 |
— not stated in the abstract
Modified Rankin scale and NIHSS scores · before discharge and at 90-day follow-up
- All scores 0
Original publication
Comparison of cerebral safety after atrial fibrillation using pulsed field and thermal ablation: Results of the neurological assessment subgroup in the ADVENT trial. Heart Rhythm. Published 31 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →