Coronary disease & ACSRandomised controlled trial
Comparison of Drug-Coated Versus Conventional Balloons for the Side Branches of Bifurcation Lesions: OCVC-BIF Study
- multicenter, randomized, open-label trial
Authors' conclusion
Additional DCB inflation in the side branch after main-vessel DES implantation with kissing balloon inflation decreases restenosis in the side branch in the treatment of bifurcation lesions.
Study context
- Population
- Patients with bifurcation lesions scheduled for drug-eluting stent (DES) implantation in the main vessel followed by kissing balloon inflationpatients randomized between October 2019 and September 2024, serial 3-dimensional bifurcation quantitative coronary angiography in 262 (87.6%)
- Participants
- 299 patients
- Comparison
- DCB group vs non-DCB group
- DCB groupn = 151
- non-DCB groupn = 148
- Primary endpoint
- Restenosis of the side branch (≥50% stenosis, 3-dimensional bifurcation quantitative coronary angiography)
- Follow-up
- scheduled coronary angiography at 9 months or symptom-driven coronary angiography during the 1-year follow-up
Primary result
As reported in the abstract
P = 0.012
Secondary outcomes
Major adverse cardiac events (key secondary end point) · 12 months · similar
P = 0.58
Original publication
Comparison of Drug-Coated Versus Conventional Balloons for the Side Branches of Bifurcation Lesions: OCVC-BIF Study. Circ Cardiovasc Interv. Published 29 May 2026. doi:10.1161/circinterventions.125.016424
Summarised from the published abstract; every number is checked against it