HypertensionRandomised controlled trial
Comparison of dual therapies for hypertension treatment in India: a randomized clinical trial
- Randomised controlled trial
- multicentre
- single-blinded
Authors' conclusion
Thus, in Indian patients, amlodipine-perindopril, perindopril-indapamide and amlodipine-indapamide were all equally well tolerated and equally highly effective in reducing 24-hour ambulatory and office BPs
Study context
- Population
- Indians aged 30–79 years with systolic blood pressure (SBP) 150–179 mmHg untreated or 140–159 mmHg on monotherapy1,637 completed ambulatory blood pressure (BP)
- Participants
- 1,981 participants
- Comparison
- Amlodipine-perindopril vs perindopril-indapamide vs amlodipine-indapamide (single-pill combinations)
- Primary endpoint
- Mean change in 24-hour ambulatory SBP
- Follow-up
- 6 months
Primary result
As reported in the abstract
Change in 24-hour ambulatory SBP
Similar large reductions in ambulatory BP in all three groups
~14/8 mmHg
Similar reductions in office BP in all three groups
~30/14 mmHg
Secondary outcomes
Hypertension control (sitting BP < 140/90 mmHg) · 6 months
- Control achieved in approximately 70% in all three groups
Mean day and night ambulatory and office BPs, hypertension control rates
- No significant differences among the study groups
Original publication
Comparison of dual therapies for hypertension treatment in India: a randomized clinical trial. Nat Med. Published 25 July 2025. doi:10.1038/s41591-025-03854-w
Summarised from the published abstract; every number is checked against it