Heart failure & cardiomyopathies
Comparison of Liver Fibrosis Scores for Predicting Mortality and Morbidity in Heart Failure with Preserved Ejection Fraction
Authors' conclusion
In light of these findings, NFS appears to have superior predictive and prognostic utility compared with AST/ALT ratio, FIB-4, BARD, and HUI scores.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) in the TOPCAT trial
- Participants
- 3,212 patients
- Comparison
- Liver fibrosis scores for predicting outcomes
- Primary endpoint
- Primary composite outcome
- Follow-up
- Median 3.3 years
Primary result
As reported in the abstract
NFS
0.672
95% CI 0.642–0.702
AUC
Hazard ratio (95% CI)
NFSper 1-point increase
1.10(1.04–1.17)
BARDper 1-point increase
1.19(1.10–1.30)
HUIper 1-point increase
1.44(1.09–1.89)
NFShigh level
1.63(1.26–2.13)
BARDhigh level
1.64(1.25–2.15)
AST/ALT ratiohigh level
1.30(1.05–1.60)
HUIhigh level
1.25(1.02–1.53)
Per 1-point increase, as printed
Further findings
Incident atrial fibrillation (AF)
| Values | HR (95% CI) | ||
|---|---|---|---|
| NFSHigh NFS | NFS AUC 0.678 (95% CI 0.622-0.734) | 2.21 (1.13–4.32) | |
| 0.20.5125Hazard ratio (log scale) |
- AUC for NFS higher than other liver fibrosis scores (LFSs)
Any hospitalization and HF hospitalization
- High NFS and Health Utilities Index (HUI) scores significant predictors
Original publication
Comparison of Liver Fibrosis Scores for Predicting Mortality and Morbidity in Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 2 March 2023. doi:10.
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