Comparison of low-density lipoprotein cholesterol equations in patients with dyslipidaemia receiving cholesterol ester transfer protein inhibition
Authors' conclusion
In European patients with dyslipidaemia receiving a CETP inhibitor, we found improved LDL-C accuracy using contemporary equations vs. the Friedewald equation, and the greatest accuracy was observed with the Martin/Hopkins equation.
Study context
- Population
- Adults aged 18–75 years with dyslipidaemia randomised to combinations of cholesterol ester transfer protein (CETP) inhibitor TA-8995 (obicetrapib), statin and placebo921 observations
- Participants
- 242 adults
- Comparison
- Friedewald vs Martin/Hopkins vs Sampson LDL-C equations, against preparative ultracentrifugation (PUC)
- Primary endpoint
- Accuracy of calculated LDL-C vs PUC LDL-C (median difference)
- Follow-up
- Pooled measurements over 12 weeks
Methodological detailsdiagnostic accuracy study, multicentre, 17 sites in the Netherlands and Denmark
- Diagnostic accuracy study
- Multicentre
- 17 sites in the Netherlands and Denmark
Primary result
As reported in the abstract
Median LDL-C difference, estimate minus PUC (overall)
Further findings
| Outcome | Friedewald | Martin/Hopkins | Sampson |
|---|---|---|---|
| Median LDL-C difference vs PUC, subgroup estimated LDL-C <1.8 mmol/L and TG 1.7-4.5 mmol/Lmmol/L | −0.25 (IQR −0.33–-0.10) | 0.00 (IQR −0.08–0.10) | −0.06 (IQR −0.13–0.00) |
| LDL-C observations <1.8 mmol/L correctly classified vs PUC, same subgroup | 71.4% | 100.0% | 93.1% |
Median LDL-C difference vs PUC, subgroup estimated LDL-C <1.8 mmol/L and TG 1.7-4.5 mmol/L
- Friedewald underestimated LDL-C
Original publication
Comparison of low-density lipoprotein cholesterol equations in patients with dyslipidaemia receiving cholesterol ester transfer protein inhibition. Eur Heart J Cardiovasc Pharmacother. Published 28 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →