Arrhythmias & electrophysiologyRandomised controlled trial
Comparison of the effectiveness and safety of dronedarone and amiodarone for preventing recurrence after catheter ablation of atrial fibrillation: an open-label randomized controlled trial
- Randomised controlled trial
- open-label
Authors' conclusion
Therapy with dronedarone during the blanking period after AF ablation was associated with a similar recurrence rate but a superior safety profile compared to amiodarone.
Study context
- Population
- Patients undergoing atrial fibrillation (AF) ablation273 in modified intention-to-treat (mITT) analysis
- Participants
- 280 patients
- Comparison
- Dronedarone vs amiodarone during the blanking period after AF ablation
- Primary endpoint
- Atrial tachyarrhythmia recurrence (>30 s)
- Follow-up
- After the blanking period
Primary result
As reported in the abstract
P = 0.184
Secondary outcomes
Secondary efficacy endpoints
- No significant differences
Safety
Side effects
P < 0.001
QTc-interval prolongation
P = 0.01
Hypothyroidism
P < 0.001
Original publication
Comparison of the effectiveness and safety of dronedarone and amiodarone for preventing recurrence after catheter ablation of atrial fibrillation: an open-label randomized controlled trial. Europace. Published 28 April 2026. doi:10.1093/europace/euag095
Summarised from the published abstract; every number is checked against it