Coronary disease & ACSSecondary analysis
Complete Revascularization and Angina-Related Health Status in the ISCHEMIA Trial
- Secondary analysis of the ISCHEMIA randomised trial
- propensity-weighted modelling
- multivariable regression
Authors' conclusion
Among patients with CCD in ISCHEMIA, health status improved more with CR compared with ICR or CON, particularly in those with frequent angina. Anatomic and functional CR provided comparable improvements in quality of life.
Study context
- Population
- Patients with chronic coronary disease randomised to invasive vs conservative management in ISCHEMIA1,641 invasive (INV) patients
- Comparison
- Complete revascularization (CR) vs incomplete revascularization (ICR) vs conservative (CON)
- Primary endpoint
- Angina-related health status (Seattle Angina Questionnaire)
- Follow-up
- 12 months
Primary result
As reported in the abstract
Angina-related health status
Anatomic CR achieved in INV patients
43.3%
Functional CR achieved in INV patients
57.8%
Further findings
Projected benefit of CR by baseline angina (subgroup)
- Most pronounced with baseline daily/weekly angina; not seen with no angina
Original publication
Complete Revascularization and Angina-Related Health Status in the ISCHEMIA Trial. J Am Coll Cardiol. Published 25 July 2023. doi:10.1016/j.jacc.2023.05.025
Summarised from the published abstract; every number is checked against it