Acute cardiac care & resuscitationSecondary analysis
Complexity of coronary artery disease in infarct-related cardiogenic shock and multivessel disease: a substudy of the DanGer Shock trial
- secondary analysis of the DanGer Shock trial
Authors' conclusion
Baseline and residual SYNTAX scores independently predicted 180-day mortality. The mAFP effect was not modified by SYNTAX measures. In the isolated left main subgroup, a hypothesis-generating signal towards a clinical benefit with mAFP use was observed.
Study context
- Population
- Patients with multivessel disease (MVD) and infarct-related cardiogenic shock (CS) in the DanGer Shock trialpatients with MVD of 355 included in DanGer Shock, 211 had an available baseline SYNTAX score, 35 had an isolated left main (LM) culprit lesion
- Participants
- 256 patients
- Comparison
- Prognostic value of baseline and residual SYNTAX scores and their influence on the effect of microaxial flow pump (mAFP) support
- Primary endpoint
- 180-day all-cause mortality
- Follow-up
- 180 days
Primary result
As reported in the abstract
Adjusted odds ratio
3.12
95% CI 1.17–8.69
high baseline SYNTAX vs low and intermediate baseline SYNTAX scores
adjusted OR 3.12 (95% CI 1.17–8.69)
Further findings
| Outcome | Values | adjusted OR (95% CI) | |
|---|---|---|---|
| 180-day all-cause mortality, isolated LM culprit lesion subgroup · lower odds with mAFP | 0.17 (0.03–0.99) | ||
| 0.050.21520Adjusted odds ratio (log scale) |
| Outcome | Values | Estimate |
|---|---|---|
| Baseline SYNTAX group distribution | low baseline SYNTAX 26% · intermediate baseline SYNTAX 47% · high baseline SYNTAX 27% |
- Baseline SYNTAX group distribution: of 211 patients with an available baseline SYNTAX score
- 180-day all-cause mortality, isolated LM culprit lesion subgroup: subgroup: 35 patients with an isolated LM culprit lesion
Residual SYNTAX score by baseline SYNTAX score
- A higher baseline SYNTAX score was associated with a higher residual SYNTAX score
- P < 0.001
180-day all-cause mortality by residual SYNTAX score
- The residual SYNTAX score independently predicted 180-day all-cause mortality
mAFP effect modification by baseline SYNTAX group
- The mAFP effect was not modified by the baseline SYNTAX group
- P for interaction = 0.31
Original publication
Complexity of coronary artery disease in infarct-related cardiogenic shock and multivessel disease: a substudy of the DanGer Shock trial. EuroIntervention. Published 5 October 2026. doi:10.4244/eij-d-26-00460
Summarised from the published abstract; every number is checked against it