Coronary disease & ACSCohort study
Comprehensive Diagnosis of Myocardial Ischemia of Obstructive and Nonobstructive Origin With a Wire-Free Diagnostic Strategy
- subanalysis of the multicenter, prospective AID-ANGIO study
Authors' conclusion
This study supports the clinical utility of a wire-free AID strategy in patients with chronic coronary syndrome, demonstrating its potential to improve diagnostic yield and guide clinical decision-making compared with coronary angiography alone. In addition, it shows substantial agreement with the wire-based approach.
Study context
- Population
- Patients with chronic coronary syndrome admitted to the catheterization laboratorypatients included
- Participants
- 262 patients
- Exposure
- wire-free advanced invasive diagnosis (AID) strategy compared with coronary angiography alone and with the wire-based AID strategy
Main finding
As reported in the abstract
Identification of a cause of myocardial ischemia
wire-free AID strategy
84.3%
2-fold increase; P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | wire-free AID strategy | coronary angiography alone | wire-based AID strategy |
|---|---|---|---|
| Change in the initial therapeutic plan compared with coronary angiography | 55.3% | Not reported in the abstract | Not reported in the abstract |
Agreement with the wire-based AID strategy
- Cohen κ
- 0.78
- substantial agreement
Therapeutic changes vs wire-based AID strategy
- therapeutic changes, wire-free vs wire-based AID strategy
- 16.8%
- good concordance
Original publication
Comprehensive Diagnosis of Myocardial Ischemia of Obstructive and Nonobstructive Origin With a Wire-Free Diagnostic Strategy. Circ Cardiovasc Interv. Published 30 January 2026. doi:10.1161/circinterventions.125.016088
Summarised from the published abstract; every number is checked against it